Atif, Muhammad
Preferred name
Atif, Muhammad
Now showing 1 - 3 of 3
- Some of the metrics are blocked by yourconsent settings
Publication Access status: Metadata only , Antimicrobial Peptide SAAP‐148‐Functionalized Hydrogels from Photocrosslinkable Polymers with Broad Antibacterial ActivityAntimicrobial peptides (AMPs) are promising alternatives to traditional antibiotics for treating skin wound infections. Nonetheless, their short half‐life in biological environments restricts clinical applicability. Covalent immobilization of AMPs onto suitable substrates offers a comprehensive solution, creating contact‐killing surfaces with long‐term functionality. Here, a copolymer of poly[(hydroxy ethyl acrylamide)‐ co ‐(4‐benzophenone acrylamide)‐ co ‐(pentafluorophenyl acrylate)‐ co ‐(ECOSURF EH‐3 acrylate)], in short poly(HEAAm‐ co ‐BPAAm‐ co ‐PFPA‐ co ‐EH3A), is synthesized by free radical polymerization. Subsequent modification of active ester groups with the amine groups of SAAP‐148, results in a copolymer, that is non‐cytotoxic to human lung fibroblasts. UV photocrosslinking of the benzophenone units yields a polymer network that forms a hydrogel after swelling with aqueous medium. Both the SAAP‐148‐modified polymer in solution and the photocrosslinked hydrogels show good antimicrobial activity against strains of Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , and Acinetobacter baumannii , including multidrug‐resistant strains, frequently found in wound infections. The covalent attachment of SAAP‐148 prevents leaching, ensuring sustained antimicrobial activity for at least 48 h in diluted human blood plasma and 14 days in PBS. This prolonged retention of antimicrobial activity in human blood plasma significantly enhances its clinical potential. Overall, this study shows the potential of the AMP‐functionalized photocrosslinkable polymer as antimicrobial wound dressings, providing an effective alternative to antibiotics.Source Type:Article1 - Some of the metrics are blocked by yourconsent settings
Publication Access status: Metadata only , Functionalization of Arabinoxylan in Chitosan Based Blends by Periodate Oxidation for Drug Release StudyThis Article presents the isolation of arabinoxylan (AX) from Plantago ovata seed husk and its oxidation using periodate to create oxidized‐AX (OAX) with distinct functionalities. Utilizing the solution casting method, biocompatible blends of arabinoxylan/chitosan (AX/CS) are prepared at various weight ratios, and their properties are assessed. Fourier transform infrared spectroscopy (FT‐IR), x‐ray diffraction (XRD), and thermogravimetric analysis (TGA) are employed to gauge compatibility and thermal traits of AX and OAX with CS. Solubility tests reveal partial and limited solubility of AX and OAX in distilled water, respectively. OAX displays favorable compressibility and flow rate through Carr's index, Hausner's ratio, and angle of repose analyses. FT‐IR data confirm intermolecular hydrogen bonding between CS′s −NH 2 − group and OAX′s carbonyl group, with XRD showing low crystallinity. Diclofenac sodium (DC) is loaded as a model drug into AX/CS and OAX/CS blends for release studies in pH 6.8 phosphate buffer. Results exhibit OAX/CS blends with sustained drug release, surpassing AX/CS blends. Among ratios tested, the OAX/CS (1 : 2) blend emerges as a superior excipient, demonstrating enhanced in‐vitro release potential, highlighting oxidized blends′ promise in sustained drug delivery systems.Source Type:Article2 - Some of the metrics are blocked by yourconsent settings
Publication Access status: Metadata only , Mixed polymer brushes for controlled protein adsorption: state of the art and future prospective(2024); Emphasizing mixed polymer brush synthesis techniques, morphologies, and their impact on protein interactions. These brushes are crucial in drug delivery, wound repair scaffolds, and biomedical fields by altering protein interactions.Source Type:Article2
