Citation Link: https://doi.org/10.1107/S1600577526002006

A pipeline for megahertz X-ray photon correlation spectroscopy on softmatter samples at the MID instrument of European XFEL

Publication Type
Article
Author(s)
Institute
Subjects
X-ray photon correlation spectroscopy
XFEL
Softmatter
DDC
530 Physik
Source
Journal of Synchrotron Radiation (2026). 33, 3, 725–738. - https://doi.org/10.1107/S1600577526002006
Date Issued
2026-02-22
Abstract
In this article, we present the experimental protocol and data-processing framework for megahertz X-ray Photon Correlation Spectroscopy (MHz XPCS) experiments on soft matter samples implemented at the Materials Imaging and Dynamics (MID) instrument of the European X-ray Free-Electron Laser (EuXFEL). Due to the introduction of a standard configuration and the implementation of a highly automated data-processing pipeline, MHz-XPCS measurements can now be conducted and analyzed with minimal user intervention. A key challenge lies in managing the extremely large data volumes generated by the Adaptive Gain Integrating Pixel Detector (AGIPD) – often reaching several petabytes within a single experiment. We describe the technical implementation, discuss the hardware requirements related to effective parallel data processing and propose strategies to enhance data quality, in particular related to data reduction strategies and an improvement of the signal-to-noise ratio. Finally, we address strategies for making the processed data FAIR (Findable, Accessible, Interoperable, Reusable), in alignment with the goals of the DAPHNE4NFDI project.
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