Skip to main content
Log In
Log in with your ZIMT Account
Log in with ORCID
Log in
New user? Click here to register.
Have you forgotten your password?
Home
Communities & Collections
Publications
People
Institution
Statistics
Help
Home
University of Siegen
DFG-funded publications (2023 - 2024)
A novel aurone RNA CAG binder inhibits the huntingtin RNA–protein interaction
Details
Citation Link:
https://doi.org/10.1039/D4MD00403E
A novel aurone RNA CAG binder inhibits the huntingtin RNA–protein interaction
Publication Type
Article
Author(s)
Ballarin, Giovanna
Biasiotto, Maddalena
Reisbitzer, Annika
Hegels, Marlen
Bolte, Michael
Krauß, Sybille
Berdnikova, Daria V.
Subjects
Huntingtin
RNA
Neurodegeneration
Mutant
Huntingtin Protein
RNA-binding protein
Messenger RNA
Cell biology
Chemistry
Biology
Molecular biology
Gene
Biochemistry
Disease
Medicine
Internal medicine
Date Issued
2024
Abstract
A novel aurone binder for CAG RNA repeats has been identified from a library of twenty-eight compounds. The ligand inhibits toxic RNA–protein interactions in the Huntington's disease model.
Show more
DOI
10.1039/D4MD00403E
URI
https://dspace.ub.uni-siegen.de/handle/ubsi/7648
Owning collection
DFG-funded publications (2023 - 2024)
