Citation link: 10.3389/fnbeh.2018.00080
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Dokument Type: Article
metadata.dc.title: Failure to replicate the association between fractional anisotropy and the serotonin transporter gene (5-HTTLPR, rs25531)
Authors: Klucken, Tim 
Tapia León, Isabell 
Blecker, Carlo 
Kruse, Onno 
Stalder, Tobias 
Stark, Rudolf 
Institute: Fakultät II Bildung, Architektur, Künste 
Free keywords: White matter microstructure integrity, Diffusion tensor imaging, Serotonin, Connectivity, Uncinate fasciculus
Dewey Decimal Classification: 150 Psychologie
GHBS-Clases: HRC
Issue Date: 2018
Publish Date: 2018
Source: Frontiers in behavioral neuroscience ; April 2018, Volume 12, Article 80. - DOI: 10.3389/fnbeh.2018.00080
Recent work underlines the importance of alterations in white matter (e.g., measured by fractional anisotropy (FA)) as a neural vulnerability marker for psychiatric disorders. In this context, the uncinate fasciculus (UF), which connects the limbic system with prefrontal areas, has repeatedly been linked to psychiatric disorders, fear processing, and anxietyrelated traits. Individual differences in FA may partly be genetically determined. Variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-HTTLPR]) is a particularly promising candidate in this context, which has been linked to psychiatric disorders as well as to limbic and prefrontal reactivity. However, findings on the association between the 5-HTTLPR and FA within the UF-tract have been heterogeneous. The present study investigated this relationship and extended previous work by considering different genetic classification approaches as well as sex effects in a human sample (n = 114). All participants were genotyped for the 5-HTTLPR and the rs25531 polymorphism. As a main result, we did not find any significant relationship between the 5-HTTLPR and FA in the UF-tract although power analyses showed an adequate power. In addition, genotype effects were neither found when different classification approaches were used nor when analyses were carried out in males or females only. The present findings suggest that the association of the 5-HTTLPR and FA seems to be a more labile phenomenon than previously assumed.
Possible explanations and limitations are discussed.
Finanziert aus dem DFG-geförderten Open-Access-Publikationsfonds der Universität Siegen für Zeitschriftenartikel
DOI: 10.3389/fnbeh.2018.00080
URN: urn:nbn:de:hbz:467-13311
Appears in Collections:Geförderte Open-Access-Publikationen

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