Citation link: 10.3389/fnbeh.2018.00080
DC FieldValueLanguage
dc.contributor.authorKlucken, Tim-
dc.contributor.authorTapia León, Isabell-
dc.contributor.authorBlecker, Carlo-
dc.contributor.authorKruse, Onno-
dc.contributor.authorStalder, Tobias-
dc.contributor.authorStark, Rudolf-
dc.date.accessioned2019-09-02T10:22:42Z-
dc.date.available2018-06-19T12:12:12Z-
dc.date.available2019-09-02T10:22:42Z-
dc.date.issued2018-
dc.descriptionFinanziert aus dem DFG-geförderten Open-Access-Publikationsfonds der Universität Siegen für Zeitschriftenartikelde
dc.description.abstractRecent work underlines the importance of alterations in white matter (e.g., measured by fractional anisotropy (FA)) as a neural vulnerability marker for psychiatric disorders. In this context, the uncinate fasciculus (UF), which connects the limbic system with prefrontal areas, has repeatedly been linked to psychiatric disorders, fear processing, and anxietyrelated traits. Individual differences in FA may partly be genetically determined. Variation in the promoter region of the serotonin transporter gene (serotonin transporter-linked polymorphic region [5-HTTLPR]) is a particularly promising candidate in this context, which has been linked to psychiatric disorders as well as to limbic and prefrontal reactivity. However, findings on the association between the 5-HTTLPR and FA within the UF-tract have been heterogeneous. The present study investigated this relationship and extended previous work by considering different genetic classification approaches as well as sex effects in a human sample (n = 114). All participants were genotyped for the 5-HTTLPR and the rs25531 polymorphism. As a main result, we did not find any significant relationship between the 5-HTTLPR and FA in the UF-tract although power analyses showed an adequate power. In addition, genotype effects were neither found when different classification approaches were used nor when analyses were carried out in males or females only. The present findings suggest that the association of the 5-HTTLPR and FA seems to be a more labile phenomenon than previously assumed. Possible explanations and limitations are discussed.en
dc.identifier.doi10.3389/fnbeh.2018.00080-
dc.identifier.urihttps://dspace.ub.uni-siegen.de/handle/ubsi/1331-
dc.identifier.urnurn:nbn:de:hbz:467-13311-
dc.language.isoende
dc.rights.urihttps://dspace.ub.uni-siegen.de/static/license.txtde
dc.sourceFrontiers in behavioral neuroscience ; April 2018, Volume 12, Article 80. - DOI: 10.3389/fnbeh.2018.00080-
dc.subject.ddc150 Psychologiede
dc.subject.otherWhite matter microstructure integrityen
dc.subject.otherDiffusion tensor imagingen
dc.subject.otherSerotoninen
dc.subject.otherConnectivityen
dc.subject.otherUncinate fasciculusen
dc.subject.swbSubstantia albade
dc.subject.swbNervenfaserbündelde
dc.subject.swbAnisotropiede
dc.subject.swbSerotoninde
dc.subject.swbDiffusionsgewichtete Magnetresonanztomografiede
dc.titleFailure to replicate the association between fractional anisotropy and the serotonin transporter gene (5-HTTLPR, rs25531)en
dc.typeArticlede
item.fulltextWith Fulltext-
ubsi.publication.affiliationFakultät II Bildung, Architektur, Künstede
ubsi.source.doi10.3389/fnbeh.2018.00080de
ubsi.source.issued2018-
ubsi.source.issuenumber8de
ubsi.source.titleFrontiers in behavioral neuroscienceen
ubsi.source.volume12de
ubsi.subject.ghbsHRCde
ubsi.subject.ghbsVYEde
ubsi.type.versionpublishedVersionde
Appears in Collections:Geförderte Open-Access-Publikationen
Files in This Item:
File Description SizeFormat
Klucken_Failure_to_Replicate.pdf889.31 kBAdobe PDFThumbnail
View/Open

This item is protected by original copyright

Show simple item record

Page view(s)

517
checked on Mar 28, 2024

Download(s)

154
checked on Mar 28, 2024

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.