Krauss, Sybille

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A novel aurone RNA CAG binder inhibits the huntingtin RNA–protein interaction
(2024)
Ballarin, Giovanna
;
Biasiotto, Maddalena
;
Reisbitzer, Annika
;
Hegels, Marlen
;
Bolte, Michael
A novel aurone binder for CAG RNA repeats has been identified from a library of twenty-eight compounds. The ligand inhibits toxic RNA–protein interactions in the Huntington's disease model.
Source Type:Article
DOI:10.1039/D4MD00403E
2
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Low Molecular Weight Inhibitors Targeting the RNA-Binding Protein HuR
(2023)
Joseph, Benjamin P.
;
Weber, Verena
;
Knüpfer, Lisa
;
Giorgetti, Alejandro
;
Alfonso‐Prieto, Mercedes
The RNA-binding protein human antigen R (HuR) regulates stability, translation, and nucleus-to-cytoplasm shuttling of its target mRNAs. This protein has been progressively recognized as a relevant therapeutic target for several pathologies, like cancer, neurodegeneration, as well as inflammation. Inhibitors of mRNA binding to HuR might thus be beneficial against a variety of diseases. Here, we present the rational identification of structurally novel HuR inhibitors. In particular, by combining chemoinformatic approaches, high-throughput virtual screening, and RNA–protein pulldown assays, we demonstrate that the 4-(2-(2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)hydrazineyl)benzoate ligand exhibits a dose-dependent HuR inhibition effect in binding experiments. Importantly, the chemical scaffold is new with respect to the currently known HuR inhibitors, opening up a new avenue for the design of pharmaceutical agents targeting this important protein.
Source Type:Article
DOI:10.3390/ijms241713127
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The dynamic world of RNA: beyond translation to subcellular localization and function
(2024)
Reisbitzer, Annika
;
Krauß, Sybille
Keywords: RNA-localization, RNA-transport, alternative polyadenylation, neurodegenerative diseases, zipcodes
Source Type:Article
DOI:10.3389/fgene.2024.1373899
2

Krauß, Sybille

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