Wiesner, Fiona
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Publication Access status: Open Access , From Concepts Towards Application: Tailored Hydrogel Systems as Versatile Materials in the Biomedical Field(2025)The rapidly evolving field of biomedicine demands innovative solutions to complex medical challenges, necessitating interdisciplinary approaches in materials development. Polymeric materials, particularly hydrogels, have emerged as vital components in addressing biomedical challenges due to their unique physicochemical properties and biocompatibility. This work investigates the development and application of hydrogel systems across three critical biomedical domains: biosensors, wound therapy, and implant technology. While these applications present distinct challenges, they share the fundamental requirement to precisely engineer the polymer architecture and the respective crosslinking mechanism. The research focuses on polymers based on 2-oxazoline and on acrylamide derivatives, respectively, which were selected for their synthetic versatility and adaptability to diverse application requirements. Various crosslinking strategies were systematically investigated, including simultaneous deprotection and crosslinking, multiphoton as well as one-photon photocrosslinking. For that, each methodology was evaluated within its specific application context. Specifically, the investigation encompasses comprehensive characterization of the resulting hydrogel systems, with particular emphasis on thermoresponsive behavior and surface properties including antifouling, anti-adhesive, and antibacterial characteristics. This thesis provides fundamental insights into both the underlying principles of tailored polymer network formation and their specific biomedical applications, contributing to the broader understanding of hydrogel-based materials in biomedicine.Source Type:Doctoral Thesis27 94 - Some of the metrics are blocked by yourconsent settings
Publication Access status: Metadata only , Thermoresponsive and Photocrosslinkable Poly(2‐alkyl‐2‐oxazoline) Toolbox – Customizable Ultralow‐Fouling Hydrogel Coatings for Blood Plasma EnvironmentsThis study focuses on developing surface coatings with excellent antifouling properties, crucial for applications in the medical, biological, and technical fields, for materials and devices in direct contact with living tissues and bodily fluids such as blood. This approach combines thermoresponsive poly(2‐alkyl‐2‐oxazoline)s, known for their inherent protein‐repellent characteristics, with established antifouling motifs based on betaines. The polymer framework is constructed from various monomer types, including a novel benzophenone‐modified 2‐oxazoline for photocrosslinking and an azide‐functionalized 2‐oxazoline, allowing subsequent modification with alkyne‐substituted antifouling motifs through copper(I)‐catalyzed azide‐alkyne cycloaddition. From these polymers surface‐attached networks are created on benzophenone‐modified gold substrates via photocrosslinking, resulting in hydrogel coatings with several micrometers thickness when swollen with aqueous media. Given that poly(2‐alkyl‐2‐oxazoline)s can exhibit a lower critical solution temperature in water, their temperature‐dependent solubility is compared to the swelling behavior of the surface‐attached hydrogels upon thermal stimulation. The antifouling performance of these hydrogel coatings in contact with human blood plasma is further evaluated by surface plasmon resonance and optical waveguide spectroscopy. All surfaces demonstrate extremely low retention of blood plasma components, even with undiluted plasma. Notably, hydrogel layers with sulfobetaine moieties allow efficient penetration by plasma components, which can then be easily removed by rinsing with buffer.Source Type:Article2
