Citation Link: https://doi.org/10.1002/cptc.202300159
Photoinduced Reactions of Styrylpyridine Derivatives for the In Situ Formation of Selective Ligands for Apyrimidinic DNA
Publication Type
Article
Subjects
Chemistry
DNA
AP site
Substituent
Ligand (biochemistry)
In situ
Fluorescence
Steric effects
Stereochemistry
Circular dichroism
Oligonucleotide
Photochemistry
DNA repair
Biochemistry
Organic chemistry
Receptor
Date Issued
2023
Abstract
The photocyclization reaction of sterically demanding styrylpyridine derivatives was investigated and shown to depend on the type of substituent. With this method, a 2,2‐diphenyl‐1,3‐benzodioxolo‐annelated benzo[ c ]quinolizinium was synthesized, and its association with regular and abasic site‐containing DNA (AP‐DNA) was investigated by absorption, fluorescence, circular and linear dichroism spectroscopy. Specifically, this ligand binds preferentially to AP‐DNA relative to regular duplex DNA, and the AP‐DNA/ligand complex is formed in situ upon irradiation of the styrylpyridine substrate in the presence of the DNA.
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